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21 In addition, there were also increased levels of proinflammatory cytokines, such as IL-1, TNF-, and IL-17, which correlated with an increased production of free radicals

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Cardones and Grichnik6 subsequently reported the transformation of existing nevi and eruption of new melanocytic nevi with atypical clinical and histologic characteristics in a 40-year-old patient with a history of dysplastic nevi and melanoma